KDM8

Across TCGA pan-cancer cohorts, KDM8 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KDM8 data layer compared with 18 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher KDM8 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated KDM8 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC, GBM, and HNSC are the cancer types where KDM8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	III,IV	0.939	0.493	.003	57	view →
GBM	DFS	Median	All	0.795	0.648	.009	14	view →
HNSC	DFS	Quartile	All	0.882	1.000	.017	11	view →
LSCC	DFS	Tertile	II,III,IV	0.791	1.000	.006	7	view →
LUAD	DFS	Tertile	All	1.000	0.726	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KDM8–CCRCC (OS)

Open the CCRCC breakdown →