KDM8

Across TCGA patient cohorts, KDM8 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDM8-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and Rad50. Each is linked with KDM8 in more than 2 cancer types. Because this analysis shows association rather than direction, both KDM8-to-partner and partner-to-KDM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by KDM8-low versus KDM8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM8→partner) and Y-score (partner→KDM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.765	+2.434	<.001	.001	3	3
UCEC	eIF4E →	+0.190	+1.925	.012	.005	3	2
UCEC	Rad50 →	-0.198	-1.925	.023	.005	3	2
UCEC	VHL →	-0.533	-1.584	.029	.034	3	2
UCEC	ATM →	-0.567	-3.584	<.001	.002	3	2
UCEC	4E-BP1 →	+0.375	+4.029	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Caspase-7-cleavedD198 by KDM8 expression — UCEC

Explore this box plot interactively →