KDM8

Across TCGA cell cohorts, KDM8 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,545 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KDM8-associated GO terms across cancer lineages are Regulation of double-strand break repair, Regulation of chromosome organization, and Regulation of DNA repair. Each is linked with KDM8 in more than 15 cancer types. Because this analysis shows association rather than direction, both KDM8-to-partner and partner-to-KDM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of double-strand break repair grouped by KDM8-low versus KDM8-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM8→partner) and Y-score (partner→KDM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of double-strand break repair →	+0.078	+0.930	<.001	<.001	3	16
SOFT_TISSUE	Regulation of chromosome organization →	+0.077	+0.689	<.001	.002	3	16
BONE	Regulation of DNA repair →	+0.071	+0.563	.001	.004	3	16
SOFT_TISSUE	Promoter clearance during DNA-templated transcription →	+0.127	+0.861	<.001	.001	3	15
SOFT_TISSUE	RNA polymerase II promoter clearance →	+0.127	+0.861	<.001	.001	3	15
BONE	DNA-templated DNA replication maintenance of fidelity →	+0.115	+0.613	.002	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,545 associations by consensus.

Regulation of double-strand break repair by KDM8 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →