KDM8

Across TCGA cell cohorts, KDM8 mutation is significantly associated with the RNA expression of many other genes, with 139 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KDM8-associated genes across cancer lineages are SPECC1L, PES1, and INTS10. Each is linked with KDM8 in more than 1 cancer types. Because this analysis shows association rather than direction, both KDM8-to-partner and partner-to-KDM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPECC1L grouped by KDM8-low versus KDM8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM8→partner) and Y-score (partner→KDM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SPECC1L →	+0.749	+3.364	.005	.002	3	1
LARGE_INTESTINE	PES1 →	+0.494	+3.537	.008	.001	3	1
LARGE_INTESTINE	INTS10 →	+0.637	+3.364	.004	.002	3	1
LARGE_INTESTINE	DCTN6 →	+0.629	+3.364	.002	.002	3	1
LARGE_INTESTINE	GPR63 →	+0.990	+3.364	<.001	.002	3	1
LARGE_INTESTINE	HDAC1 →	+0.684	+3.364	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 139 associations by consensus.

SPECC1L by KDM8 expression — LARGE_INTESTINE

Explore this box plot interactively →