KDM6B

Across TCGA patient cohorts, KDM6B mutation is significantly associated with the RNA expression of many other genes, with 4,859 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDM6B-associated genes across cancer lineages are TYW3, SPDL1, and GEMIN2. Each is linked with KDM6B in more than 3 cancer types. Because this analysis shows association rather than direction, both KDM6B-to-partner and partner-to-KDM6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TYW3 grouped by KDM6B-low versus KDM6B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM6B→partner) and Y-score (partner→KDM6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TYW3 →	+0.422	+3.291	<.001	<.001	3	4
UCEC	SPDL1 →	+0.490	+3.010	.001	<.001	3	4
UCEC	GEMIN2 →	+0.351	+2.280	.003	<.001	3	4
UCEC	GNPNAT1 →	+0.608	+2.295	<.001	<.001	3	4
UCEC	ERI1 →	+0.603	+3.413	<.001	<.001	3	4
UCEC	P4HA1 →	+0.482	+1.858	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,859 associations by consensus.

TYW3 by KDM6B expression — UCEC

Explore this box plot interactively →