KDM6B

Across TCGA pan-cancer cohorts, KDM6B RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of KDM6B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KDM6B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KDM6B is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

HNSC, KICH, and BLCA are the cancer types where KDM6B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KDM6B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.007	<.001	10	view →
KICH	All	All	−0.970	<.001	8	view →
BLCA	Female	III,IV	−0.844	.019	4	view →
LUAD	All	All	−0.783	<.001	4	view →
LUSC	Male	All	−0.714	<.001	4	view →
THCA	Female	All	−0.567	<.001	4	view →
BRCA	Female	All	−0.364	<.001	4	view →
KIRC	All	All	+0.379	<.001	3	view →
UCEC	All	IV	−1.365	.037	2	view →
ESCA	Female	All	+1.019	.003	2	view →
CHOL	All	All	+0.938	.003	2	view →
PAAD	Female	All	+0.660	.036	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

KDM6B–HNSC

Open the HNSC breakdown →