KDM6B

Across TCGA patient cohorts, KDM6B mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDM6B-associated genes across cancer lineages are 4E-BP1, ASNS, and MSH2. Each is linked with KDM6B in more than 2 cancer types. Because this analysis shows association rather than direction, both KDM6B-to-partner and partner-to-KDM6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by KDM6B-low versus KDM6B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM6B→partner) and Y-score (partner→KDM6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.352	+1.807	<.001	<.001	3	3
COAD	ASNS →	+0.364	+1.882	.028	.031	3	3
COAD	MSH2 →	-0.303	-3.169	.001	.017	3	2
UCEC	MSH6 →	-0.305	-2.222	.001	.009	3	2
UCEC	Notch1 →	+0.124	+1.584	.003	.002	3	2
UCEC	PCNA →	+0.202	+1.378	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

4E-BP1 by KDM6B expression — UCEC

Explore this box plot interactively →