KDM6B

Across TCGA cell cohorts, KDM6B mutation is significantly associated with the RNA expression of many other genes, with 381 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KDM6B-associated genes across cancer lineages are ADIPOQ, ACSM5, and PABPC1L2A. Each is linked with KDM6B in more than 1 cancer types. Because this analysis shows association rather than direction, both KDM6B-to-partner and partner-to-KDM6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADIPOQ grouped by KDM6B-low versus KDM6B-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM6B→partner) and Y-score (partner→KDM6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ADIPOQ →	+0.003	+3.217	<.001	.006	3	2
SKIN	ACSM5 →	+0.991	+3.643	.003	.005	3	2
LUNG_NSCLC_LUAD	PABPC1L2A →	+0.045	+4.887	<.001	.009	3	2
CNS	SHOX →	+0.327	+4.771	<.001	<.001	3	2
LARGE_INTESTINE	NOL9 →	+0.637	+2.265	.001	.001	3	2
OESOPHAGUS	C10orf53 →	+0.023	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 381 associations by consensus.

ADIPOQ by KDM6B expression — SKIN

Explore this box plot interactively →