KDM6A

Across TCGA patient cohorts, KDM6A mutation is significantly associated with the RNA expression of many other genes, with 7,674 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDM6A-associated genes across cancer lineages are ACTR6, POLR1F, and NUFIP2. Each is linked with KDM6A in more than 3 cancer types. Because this analysis shows association rather than direction, both KDM6A-to-partner and partner-to-KDM6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACTR6 grouped by KDM6A-low versus KDM6A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM6A→partner) and Y-score (partner→KDM6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACTR6 →	+0.478	+2.403	<.001	<.001	3	4
UCEC	POLR1F →	+0.438	+1.447	<.001	<.001	3	3
LUSC	NUFIP2 →	+0.471	+2.718	<.001	.003	3	3
LUSC	KLHL12 →	+0.332	+3.357	.006	.004	3	3
LUSC	FAM189A2 →	-0.837	-2.898	<.001	.001	3	3
UCEC	SUCLA2 →	+0.667	+1.436	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,674 associations by consensus.

ACTR6 by KDM6A expression — UCEC

Explore this box plot interactively →