KDM5B

Across TCGA pan-cancer cohorts, KDM5B mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KDM5B data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher KDM5B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated KDM5B expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

PDAC, LSCC, and UCEC are the cancer types where KDM5B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	III,IV	0.412	0.923	.004	41	view →
LSCC	OS	Median	II,III,IV	0.900	0.564	.001	14	view →
UCEC	DFS	Median	II,III,IV	0.882	0.533	.035	4	view →
LUAD	DFS	Median	III,IV	1.000	0.498	.017	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KDM5B–PDAC (DFS)

Open the PDAC breakdown →