KDM5B

Across TCGA pan-cancer cohorts, KDM5B RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of KDM5B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KDM5B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KDM5B is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

HNSC, BLCA, and LUSC are the cancer types where KDM5B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KDM5B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.265	<.001	12	view →
BLCA	Male	III,IV	+1.609	<.001	11	view →
LUSC	Female	All	+1.498	<.001	9	view →
LUAD	Male	All	+1.240	<.001	9	view →
LIHC	Female	II,III,IV	+1.384	<.001	8	view →
BRCA	All	III,IV	+1.279	<.001	6	view →
UCEC	All	All	+0.844	<.001	6	view →
CHOL	Male	All	+3.381	<.001	5	view →
KICH	Female	All	−1.009	<.001	5	view →
KIRP	All	II,III,IV	+0.694	.011	5	view →
STAD	All	II,III,IV	+0.566	.027	5	view →
KIRC	All	All	+0.229	.015	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

KDM5B–HNSC

Open the HNSC breakdown →