KDM5B

Across TCGA patient cohorts, KDM5B mutation is significantly associated with the RNA expression of many other genes, with 4,526 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDM5B-associated genes across cancer lineages are RPL17P50, CPE, and C4orf46. Each is linked with KDM5B in more than 4 cancer types. Because this analysis shows association rather than direction, both KDM5B-to-partner and partner-to-KDM5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL17P50 grouped by KDM5B-low versus KDM5B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM5B→partner) and Y-score (partner→KDM5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPL17P50 →	+0.485	+3.352	.008	.005	3	5
CESC	CPE →	-1.863	-3.321	<.001	.008	3	4
SKCM	C4orf46 →	+0.561	+2.729	.002	.003	3	4
UCEC	HAUS1 →	+0.378	+1.169	.002	.006	3	4
UCEC	MAD2L1 →	+0.505	+1.301	.003	.002	3	4
UCEC	TRAPPC2L →	+0.309	+1.503	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,526 associations by consensus.

RPL17P50 by KDM5B expression — COAD

Explore this box plot interactively →