KDM5B

Across TCGA cell cohorts, KDM5B mutation is significantly associated with the RNA expression of many other genes, with 388 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KDM5B-associated genes across cancer lineages are C17orf50, HHLA1, and CCDC134. Each is linked with KDM5B in more than 1 cancer types. Because this analysis shows association rather than direction, both KDM5B-to-partner and partner-to-KDM5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C17orf50 grouped by KDM5B-low versus KDM5B-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM5B→partner) and Y-score (partner→KDM5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	C17orf50 →	+0.155	+3.712	.002	.009	3	2
BLOOD_Leukemia	HHLA1 →	+0.005	+2.644	<.001	.008	3	2
LARGE_INTESTINE	CCDC134 →	+0.799	+3.301	<.001	.003	3	2
LARGE_INTESTINE	PIMREG →	+0.865	+3.502	.002	.001	3	2
LARGE_INTESTINE	MPDU1 →	+0.601	+2.451	.001	.009	3	2
LARGE_INTESTINE	TLR3 →	+1.086	+3.082	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 388 associations by consensus.

C17orf50 by KDM5B expression — CNS

Explore this box plot interactively →