KDM4E

Across TCGA patient cohorts, KDM4E mutation is significantly associated with the RNA expression of many other genes, with 1,506 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDM4E-associated genes across cancer lineages are RNA5SP422, RNU6-1213P, and RNA5SP509. Each is linked with KDM4E in more than 1 cancer types. Because this analysis shows association rather than direction, both KDM4E-to-partner and partner-to-KDM4E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP422 grouped by KDM4E-low versus KDM4E-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM4E→partner) and Y-score (partner→KDM4E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP422 →	+0.589	+1.841	<.001	.003	3	2
UCEC	RNU6-1213P →	+0.148	+3.002	<.001	.006	3	2
LUSC	RNA5SP509 →	+0.373	+7.924	<.001	.008	3	2
SKCM	VN1R3 →	+0.046	+5.867	<.001	.003	3	2
SKCM	RNU6-1292P →	+0.352	+6.469	<.001	.001	3	2
BRCA	RN7SKP83 →	+0.165	+4.575	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,506 associations by consensus.

RNA5SP422 by KDM4E expression — UCEC

Explore this box plot interactively →