KDM4E

Across TCGA pan-cancer cohorts, KDM4E RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated KDM4E data layer compared with 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KDM4E RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated KDM4E expression acts as an unfavorable survival marker, although some lineages such as HNSC and THCA show a favorable association.

HNSC, THCA, and UCEC are the cancer types where KDM4E RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.727	0.562	<.001	130	view →
THCA	DFS	Quartile	IV	0.968	0.545	.003	51	view →
UCEC	OS	Median	III,IV	0.789	0.474	.014	38	view →
ACC	DFS	Median	IV	0.158	0.532	.002	23	view →
LUSC	OS	Median	II,III,IV	0.664	0.786	.024	20	view →
READ	DFS	Quartile	All	0.652	0.898	.004	18	view →
THYM	DFS	Median	III,IV	1.000	0.512	.015	16	view →
DLBC	OS	Quartile	II,III,IV	0.657	1.000	.019	15	view →
OV	OS	Tertile	III,IV	0.766	0.860	.016	14	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	12	view →
BRCA	DFS	Tertile	IV	0.414	0.741	.036	12	view →
LIHC	DFS	Quartile	III,IV	0.708	0.275	.023	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

KDM4E–HNSC (DFS)

Open the HNSC breakdown →