KDM4E

Across TCGA patient cohorts, KDM4E mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDM4E-associated genes across cancer lineages are ATM, Cyclin-B1, and 14-3-3_beta. Each is linked with KDM4E in more than 1 cancer types. Because this analysis shows association rather than direction, both KDM4E-to-partner and partner-to-KDM4E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by KDM4E-low versus KDM4E-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM4E→partner) and Y-score (partner→KDM4E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.538	-3.446	.001	.005	3	2
UCEC	Cyclin-B1 →	+0.879	+2.736	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.098	-1.847	.008	.049	3	1
UCEC	EGFR_pY1068 →	-0.211	-1.502	.022	.030	3	1
UCEC	eIF4G →	+0.355	+2.807	.001	.003	3	1
UCEC	A-Raf_pS299 →	-0.120	-2.222	.006	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

ATM by KDM4E expression — UCEC

Explore this box plot interactively →