KDM4E

Across TCGA cell cohorts, KDM4E mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible KDM4E-associated genes across cancer lineages are MMP27, OR2T8, and KRT36. Each is linked with KDM4E in more than 1 cancer types. Because this analysis shows association rather than direction, both KDM4E-to-partner and partner-to-KDM4E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP27 grouped by KDM4E-low versus KDM4E-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM4E→partner) and Y-score (partner→KDM4E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MMP27 →	+0.006	+5.614	<.001	.002	3	1
LARGE_INTESTINE	OR2T8 →	+0.147	+3.693	.005	.005	3	1
LUNG_NSCLC_LUAD	KRT36 →	+0.082	+4.087	<.001	.001	3	1
LUNG_NSCLC_LUAD	TSGA10IP →	+0.210	+3.882	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MMP27 by KDM4E expression — PANCREAS

Explore this box plot interactively →