Across TCGA cell cohorts, KDM4D mutation is significantly associated with the RNA expression of many other genes, with 115 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KDM4D-associated genes across cancer lineages are AHSP, OR8D4, and C8orf34. Each is linked with KDM4D in more than 1 cancer types. Because this analysis shows association rather than direction, both KDM4D-to-partner and partner-to-KDM4D results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM4D→partner) and Y-score (partner→KDM4D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	AHSP →	+0.905	+4.070	<.001	.003	3	2
LUNG_SCLC	OR8D4 →	+0.048	+3.736	.001	.007	3	1
BLOOD_Leukemia	C8orf34 →	+0.114	+3.769	<.001	.008	3	1
BLOOD_Leukemia	INSM2 →	+0.311	+3.769	<.001	.008	3	1
BLOOD_Leukemia	TCERG1L →	+1.784	+4.066	<.001	.004	3	1
BLOOD_Leukemia	LHFPL5 →	+0.064	+3.999	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 115 associations by consensus.

Exploration

KDM4D survival (RNA) · tumor vs normal (RNA) · all KDM4D data types