KDM4B

Across TCGA patient cohorts, KDM4B mutation is significantly associated with the total protein of many other genes, with 93 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDM4B-associated genes across cancer lineages are Caspase-8, Axl, and CDK1. Each is linked with KDM4B in more than 3 cancer types. Because this analysis shows association rather than direction, both KDM4B-to-partner and partner-to-KDM4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by KDM4B-low versus KDM4B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM4B→partner) and Y-score (partner→KDM4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Caspase-8 →	-0.247	-2.966	<.001	.034	3	3
COAD	Axl →	-0.328	-1.682	.001	.043	3	3
COAD	CDK1 →	+0.233	+1.815	<.001	.016	3	3
COAD	EGFR_pY1068 →	-0.318	-1.798	.009	.026	3	2
UCEC	Fibronectin →	-0.232	-2.077	.025	.005	3	2
SKCM	Akt_pT308 →	+0.700	+2.459	.003	.020	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 93 associations by consensus.

Caspase-8 by KDM4B expression — SKCM

Explore this box plot interactively →