KDM4B

Across TCGA cell cohorts, KDM4B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,804 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible KDM4B-associated GO terms across cancer lineages are Positive regulation of anaphase-promoting complex-dependent catabolic process, Positive regulation of autophagy, and Cytosolic transport. Each is linked with KDM4B in more than 16 cancer types. Because this analysis shows association rather than direction, both KDM4B-to-partner and partner-to-KDM4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of anaphase-promoting complex-dependent catabolic process grouped by KDM4B-low versus KDM4B-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM4B→partner) and Y-score (partner→KDM4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.154	+0.736	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Positive regulation of autophagy →	+0.067	+0.683	<.001	<.001	3	16
OESOPHAGUS	Cytosolic transport →	+0.084	+0.909	<.001	.001	3	16
SOFT_TISSUE	Positive regulation of autophagy of mitochondrion →	+0.095	+0.766	<.001	<.001	3	16
LIVER	Negative regulation of protein localization to chromatin →	+0.145	+0.819	.001	<.001	3	15
LUNG_SCLC	Symbiont-mediated disruption of host cellular anatomical structure →	+0.124	+0.768	<.001	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,804 associations by consensus.

Positive regulation of anaphase-promoting complex-dependent catabolic process by KDM4B expression — BONE

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