KDM4A

Across TCGA pan-cancer cohorts, KDM4A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KDM4A data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher KDM4A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated KDM4A expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, CCRCC, and LSCC are the cancer types where KDM4A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	1.000	0.793	.015	8	view →
CCRCC	OS	Quartile	III,IV	0.542	0.982	.016	8	view →
LSCC	OS	Tertile	II,III,IV	0.895	0.500	.005	6	view →
PDAC	DFS	Quartile	II,III,IV	0.618	0.933	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KDM4A–LUAD (OS)

Open the LUAD breakdown →