KDM4A

Across TCGA patient cohorts, KDM4A protein abundance is significantly associated with the RNA expression of many other genes, with 12,489 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible KDM4A-associated genes across cancer lineages are CDCA8, TROAP, and KIF2C. Each is linked with KDM4A in more than 5 cancer types. Because this analysis shows association rather than direction, both KDM4A-to-partner and partner-to-KDM4A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KDM4A versus CDCA8 in HNSC, with a Pearson correlation of 0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM4A→partner) and Y-score (partner→KDM4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CDCA8 →	+1.316	+0.596	<.001	<.001	3	6
UCEC	TROAP →	+1.021	+0.272	<.001	<.001	3	6
HNSC	KIF2C →	+1.071	+0.548	<.001	<.001	3	6
HNSC	SUV39H2 →	+0.844	+0.516	<.001	<.001	3	6
BRCA	PPIH →	+0.516	+0.258	<.001	<.001	3	6
GBM	EXO1 →	+0.979	+0.326	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,489 associations by consensus.

KDM4A vs CDCA8 — HNSC

Explore this scatter interactively →