KDM4A

Across TCGA patient cohorts, KDM4A mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDM4A-associated genes across cancer lineages are PCNA, eIF4G, and A-Raf_pS299. Each is linked with KDM4A in more than 1 cancer types. Because this analysis shows association rather than direction, both KDM4A-to-partner and partner-to-KDM4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by KDM4A-low versus KDM4A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM4A→partner) and Y-score (partner→KDM4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.270	+3.008	.036	.019	3	2
UCEC	eIF4G →	+0.262	+2.807	.011	.003	3	2
UCEC	A-Raf_pS299 →	-0.083	-2.000	.038	.030	3	2
UCEC	MEK1 →	+0.444	+3.906	<.001	<.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.525	-2.247	<.001	.001	3	2
UCEC	Rictor_pT1135 →	-0.094	-1.906	.006	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

PCNA by KDM4A expression — COAD

Explore this box plot interactively →