KDM4A

Across TCGA cell cohorts, KDM4A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,918 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KDM4A-associated GO terms across cancer lineages are Positive regulation of mRNA metabolic process, Epigenetic regulation of gene expression, and RNA destabilization. Each is linked with KDM4A in more than 14 cancer types. Because this analysis shows association rather than direction, both KDM4A-to-partner and partner-to-KDM4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mRNA metabolic process grouped by KDM4A-low versus KDM4A-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM4A→partner) and Y-score (partner→KDM4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of mRNA metabolic process →	+0.058	+0.593	<.001	.002	3	15
BONE	Epigenetic regulation of gene expression →	+0.059	+0.817	.006	.005	3	15
STOMACH	RNA destabilization →	+0.068	+0.927	<.001	.006	3	15
STOMACH	mRNA destabilization →	+0.071	+1.024	<.001	.001	3	15
UPPER_AERODIGESTIVE_TRACT	Positive regulation of TORC2 signaling →	+0.095	+0.661	<.001	<.001	3	14
LARGE_INTESTINE	Heterochromatin formation →	+0.052	+0.645	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,918 associations by consensus.

Positive regulation of mRNA metabolic process by KDM4A expression — SOFT_TISSUE

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