KDM4A

Across TCGA cell cohorts, KDM4A mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KDM4A-associated genes across cancer lineages are TRIM49, XAGE5, and MEIKIN. Each is linked with KDM4A in more than 1 cancer types. Because this analysis shows association rather than direction, both KDM4A-to-partner and partner-to-KDM4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM49 grouped by KDM4A-low versus KDM4A-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM4A→partner) and Y-score (partner→KDM4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TRIM49 →	+0.013	+5.087	<.001	.004	3	1
URINARY_TRACT	XAGE5 →	+0.353	+5.087	<.001	.004	3	1
URINARY_TRACT	MEIKIN →	+0.476	+5.087	<.001	.004	3	1
URINARY_TRACT	OR8K3 →	+0.033	+5.087	<.001	.004	3	1
LARGE_INTESTINE	TBX22 →	+0.026	+3.217	<.001	.006	3	1
LARGE_INTESTINE	BPIFB6 →	+0.014	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

TRIM49 by KDM4A expression — URINARY_TRACT

Explore this box plot interactively →