KDM4A-AS1

Across TCGA pan-cancer cohorts, KDM4A-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated KDM4A-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher KDM4A-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KDM4A-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LUSC show a favorable association.

KIRC, ACC, and KICH are the cancer types where KDM4A-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.495	0.717	<.001	163	view →
ACC	DFS	Median	All	0.210	0.684	<.001	142	view →
KICH	DFS	Median	All	0.668	1.000	<.001	103	view →
LIHC	OS	Median	All	0.696	0.859	<.001	62	view →
LGG	DFS	Median	All	0.603	0.869	<.001	54	view →
COAD	DFS	Median	II,III,IV	0.544	0.733	.001	41	view →
SARC	OS	Quartile	All	0.407	0.817	<.001	24	view →
UVM	DFS	Quartile	III,IV	0.239	0.746	.024	20	view →
KIRP	DFS	Median	IV	0.037	0.527	.004	20	view →
MESO	DFS	Median	II,III,IV	0.238	0.663	.003	15	view →
DLBC	DFS	Tertile	All	0.611	1.000	.003	13	view →
LUAD	OS	Median	II,III,IV	0.355	0.180	.009	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

KDM4A-AS1–KIRC (DFS)

Open the KIRC breakdown →