KDM4A-AS1

Across TCGA pan-cancer cohorts, KDM4A-AS1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of KDM4A-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KDM4A-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KDM4A-AS1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, STAD, and LIHC are the cancer types where KDM4A-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KDM4A-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.973	<.001	11	view →
STAD	All	II,III,IV	+0.685	<.001	9	view →
LIHC	Male	All	+0.615	<.001	9	view →
LUSC	Female	All	+1.391	<.001	8	view →
BLCA	All	III,IV	+0.908	<.001	8	view →
COAD	Male	II,III,IV	+0.382	<.001	8	view →
LUAD	Female	All	+0.492	<.001	7	view →
UCEC	All	All	+0.621	.001	6	view →
BRCA	All	II,III,IV	+0.223	.005	6	view →
CHOL	Male	All	+1.184	<.001	5	view →
KIRP	All	All	+0.208	.033	5	view →
KIRC	All	All	+0.137	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

KDM4A-AS1–HNSC

Open the HNSC breakdown →