KDM3A

Across TCGA pan-cancer cohorts, KDM3A Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated KDM3A data layer compared with 27 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher KDM3A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KDM3A expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

MESO, LIHC, and LUAD are the cancer types where KDM3A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	III,IV	0.052	0.567	<.001	36	view →
LIHC	OS	Median	All	0.059	0.777	<.001	36	view →
LUAD	DFS	Median	All	0.266	0.815	<.001	11	view →
UCEC	DFS	Median	All	0.965	0.625	.015	10	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
BRCA	OS	Median	III,IV	0.647	0.906	.016	6	view →
STAD	OS	Median	IV	0.805	0.283	.031	6	view →
HNSC	OS	Median	All	0.201	0.687	.013	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

KDM3A–MESO (OS)

Open the MESO breakdown →