KDM3A

Across TCGA pan-cancer cohorts, KDM3A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KDM3A data layer compared with 27 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher KDM3A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated KDM3A expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

PDAC, LSCC, and CCRCC are the cancer types where KDM3A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	II,III,IV	0.243	0.515	.001	44	view →
LSCC	DFS	Quartile	II,III,IV	0.933	0.344	<.001	24	view →
CCRCC	OS	Median	All	0.891	1.000	.004	16	view →
LUAD	DFS	Median	II,III,IV	1.000	0.798	.015	6	view →
UCEC	DFS	Tertile	II,III,IV	0.904	0.485	.047	4	view →
HNSC	OS	Median	All	1.000	0.960	.026	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KDM3A–PDAC (DFS)

Open the PDAC breakdown →