KDM2B

Across TCGA patient cohorts, KDM2B mutation is significantly associated with the RNA expression of many other genes, with 4,735 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDM2B-associated genes across cancer lineages are DNAJA3, SLC25A11, and RFC5. Each is linked with KDM2B in more than 3 cancer types. Because this analysis shows association rather than direction, both KDM2B-to-partner and partner-to-KDM2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAJA3 grouped by KDM2B-low versus KDM2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM2B→partner) and Y-score (partner→KDM2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DNAJA3 →	+0.450	+1.710	<.001	<.001	3	4
UCEC	SLC25A11 →	+0.295	+2.084	.002	.001	3	4
UCEC	RFC5 →	+0.463	+2.008	<.001	<.001	3	4
SKCM	GOT1 →	+0.410	+2.632	.003	.005	3	4
UCEC	POC1A →	+0.514	+2.523	<.001	<.001	3	4
SKCM	ENO1 →	+0.507	+2.720	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,735 associations by consensus.

DNAJA3 by KDM2B expression — UCEC

Explore this box plot interactively →