KDM2B

Across TCGA pan-cancer cohorts, KDM2B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of KDM2B’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where KDM2B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KDM2B is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

COAD, KIRP, and KIRC are the cancer types where KDM2B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KDM2B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+0.740	<.001	12	view →
KIRP	All	All	+0.475	<.001	11	view →
KIRC	Female	All	+0.410	<.001	11	view →
BLCA	All	All	+0.506	<.001	8	view →
THCA	All	II,III,IV	−0.417	<.001	8	view →
STAD	All	II,III,IV	+0.830	<.001	7	view →
LUSC	All	II,III,IV	+0.504	<.001	6	view →
BRCA	All	II,III,IV	+0.344	<.001	6	view →
CHOL	Male	All	+1.281	<.001	5	view →
HNSC	Male	All	+0.491	.001	5	view →
LIHC	All	All	+0.344	<.001	3	view →
UCEC	All	III,IV	+0.574	.039	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

KDM2B–COAD

Open the COAD breakdown →