KDM2B

Across TCGA patient cohorts, KDM2B mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDM2B-associated genes across cancer lineages are Cyclin-B1, Caspase-7-cleavedD198, and eEF2. Each is linked with KDM2B in more than 3 cancer types. Because this analysis shows association rather than direction, both KDM2B-to-partner and partner-to-KDM2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by KDM2B-low versus KDM2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM2B→partner) and Y-score (partner→KDM2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.598	+2.247	<.001	.001	3	3
COAD	Caspase-7-cleavedD198 →	+1.985	+2.824	<.001	.034	3	3
STAD	eEF2 →	+0.351	+3.321	.013	.010	3	2
STAD	c-Kit →	-0.427	-3.321	.004	.010	2	3
STAD	4E-BP1 →	+0.328	+3.000	.019	.034	3	2
COAD	MEK1 →	+0.293	+2.832	.007	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Cyclin-B1 by KDM2B expression — UCEC

Explore this box plot interactively →