KDM2A

Across TCGA pan-cancer cohorts, KDM2A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KDM2A data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher KDM2A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KDM2A expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, LUAD, and PDAC are the cancer types where KDM2A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.886	0.691	.001	58	view →
LUAD	DFS	Median	III,IV	0.977	0.504	.005	34	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	9	view →
HNSC	OS	Median	IV	0.768	0.905	.022	6	view →
UCEC	DFS	Quartile	All	0.775	0.953	.023	4	view →
CCRCC	OS	Median	All	0.905	0.984	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KDM2A–LSCC (DFS)

Open the LSCC breakdown →