KDM1B

Across TCGA patient cohorts, KDM1B mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDM1B-associated genes across cancer lineages are Notch1, S6_pS240_S244, and BRCA2. Each is linked with KDM1B in more than 1 cancer types. Because this analysis shows association rather than direction, both KDM1B-to-partner and partner-to-KDM1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by KDM1B-low versus KDM1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM1B→partner) and Y-score (partner→KDM1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.150	+1.335	<.001	.041	3	2
UCEC	S6_pS240_S244 →	+0.268	+1.523	.039	.008	3	2
UCEC	BRCA2 →	-0.086	-1.215	.036	.035	3	2
UCEC	Di-Ras3 →	-0.109	-2.102	.021	.016	3	2
UCEC	FoxM1 →	+0.202	+2.331	.014	.003	3	1
UCEC	IGFBP2 →	-0.542	-1.584	.009	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Notch1 by KDM1B expression — UCEC

Explore this box plot interactively →