KDM1A

Across TCGA pan-cancer cohorts, KDM1A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KDM1A data layer compared with 21 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher KDM1A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated KDM1A expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where KDM1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	All	0.918	0.722	.003	23	view →
PDAC	OS	Median	III,IV	0.327	0.830	.005	13	view →
HNSC	OS	Tertile	II,III,IV	1.000	0.949	.043	2	view →
CCRCC	OS	Median	II,III,IV	0.612	0.862	.005	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KDM1A–LSCC (OS)

Open the LSCC breakdown →