KDM1A

Across TCGA patient cohorts, KDM1A mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDM1A-associated genes across cancer lineages are ERK2, MSH2, and PDCD4. Each is linked with KDM1A in more than 1 cancer types. Because this analysis shows association rather than direction, both KDM1A-to-partner and partner-to-KDM1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by KDM1A-low versus KDM1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM1A→partner) and Y-score (partner→KDM1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.191	+2.247	.007	.001	3	2
UCEC	MSH2 →	-0.303	-2.105	<.001	.017	3	2
UCEC	PDCD4 →	-0.524	-2.000	.002	.029	3	2
UCEC	TFRC →	+0.444	+2.321	.022	.033	3	2
UCEC	ATM →	-0.666	-3.392	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.096	-3.558	.009	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

ERK2 by KDM1A expression — UCEC

Explore this box plot interactively →