KDELR1

Across TCGA patient cohorts, KDELR1 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDELR1-associated genes across cancer lineages are GAPDH, ATM, and Caspase-7-cleavedD198. Each is linked with KDELR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KDELR1-to-partner and partner-to-KDELR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by KDELR1-low versus KDELR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDELR1→partner) and Y-score (partner→KDELR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.464	+2.321	.036	.034	3	2
UCEC	ATM →	-0.719	-3.446	<.001	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.905	+1.894	<.001	.030	3	2
UCEC	14-3-3_beta →	-0.105	-3.295	.011	.009	3	1
UCEC	eEF2 →	+0.555	+3.459	<.001	.005	2	2
UCEC	EGFR_pY1068 →	-0.256	-2.321	.013	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

GAPDH by KDELR1 expression — UCEC

Explore this box plot interactively →