KDELR1

Across TCGA pan-cancer cohorts, KDELR1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of KDELR1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KDELR1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KDELR1 is over-expressed in tumor.

HNSC, KIRP, and BLCA are the cancer types where KDELR1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KDELR1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.047	<.001	12	view →
KIRP	All	II,III,IV	+0.725	<.001	11	view →
BLCA	All	All	+0.736	<.001	10	view →
KIRC	Female	All	+0.413	<.001	10	view →
LIHC	Female	II,III,IV	+1.120	<.001	9	view →
LUAD	Male	III,IV	+0.993	<.001	9	view →
STAD	All	All	+0.898	<.001	9	view →
LUSC	Male	II,III,IV	+0.690	<.001	7	view →
COAD	Male	II,III,IV	+0.471	<.001	7	view →
BRCA	All	III,IV	+0.823	<.001	6	view →
CHOL	Male	All	+1.916	<.001	5	view →
ESCA	All	All	+1.038	.004	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

KDELR1–HNSC

Open the HNSC breakdown →