KCTD4

Across TCGA pan-cancer cohorts, KCTD4 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated KCTD4 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher KCTD4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated KCTD4 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

BRCA, LUAD, and SKCM are the cancer types where KCTD4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	All	0.294	0.903	<.001	6	view →
LUAD	DFS	Median	All	0.049	0.814	<.001	6	view →
SKCM	DFS	Median	II,III,IV	1.000	0.218	.030	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

KCTD4–BRCA (DFS)

Open the BRCA breakdown →