KCTD4

Across TCGA pan-cancer cohorts, KCTD4 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of KCTD4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where KCTD4 RNA is repressed in tumor relative to normal tissue. In most cancer types KCTD4 is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, HNSC, and THCA are the cancer types where KCTD4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCTD4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	−1.144	<.001	11	view →
HNSC	All	II,III,IV	−0.271	<.001	8	view →
THCA	All	II,III,IV	−0.057	<.001	7	view →
KIRC	Male	II,III,IV	+0.521	<.001	6	view →
BRCA	All	III,IV	−0.373	<.001	6	view →
READ	All	All	−1.003	.001	5	view →
KICH	Female	All	−0.629	<.001	4	view →
KIRP	All	All	+0.790	<.001	3	view →
STAD	All	All	−0.211	.001	3	view →
PRAD	All	All	−0.070	.045	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

KCTD4–COAD

Open the COAD breakdown →