KCTD4

Across TCGA patient cohorts, KCTD4 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCTD4-associated genes across cancer lineages are p38-MAPK_pT180_Y182, eEF2, and A-Raf_pS299. Each is linked with KCTD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCTD4-to-partner and partner-to-KCTD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by KCTD4-low versus KCTD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCTD4→partner) and Y-score (partner→KCTD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.553	-2.571	.008	.011	3	2
UCEC	eEF2 →	+0.352	+2.584	.034	.011	3	1
UCEC	A-Raf_pS299 →	-0.142	-3.000	.010	.036	3	1
UCEC	Gab2 →	+0.458	+3.000	.005	.036	3	1
UCEC	JNK2 →	+0.273	+3.700	.003	.001	3	1
UCEC	Ku80 →	+0.220	+1.887	.045	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

p38-MAPK_pT180_Y182 by KCTD4 expression — UCEC

Explore this box plot interactively →