KCTD3

Across TCGA cell cohorts, KCTD3 mutation is significantly associated with the RNA expression of many other genes, with 349 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCTD3-associated genes across cancer lineages are GPR63, ADNP2, and RBFA. Each is linked with KCTD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCTD3-to-partner and partner-to-KCTD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR63 grouped by KCTD3-low versus KCTD3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCTD3→partner) and Y-score (partner→KCTD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GPR63 →	+0.882	+3.212	<.001	.006	3	2
LARGE_INTESTINE	ADNP2 →	+0.771	+3.212	.002	.006	3	1
LARGE_INTESTINE	RBFA →	+0.757	+3.212	.003	.006	3	1
LARGE_INTESTINE	RNF125 →	+1.169	+3.212	<.001	.006	3	1
LARGE_INTESTINE	DNASE2 →	+0.909	+3.212	.004	.006	3	1
LARGE_INTESTINE	RPS12 →	+0.539	+3.212	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 349 associations by consensus.

GPR63 by KCTD3 expression — LARGE_INTESTINE

Explore this box plot interactively →