KCTD1

Across TCGA patient cohorts, KCTD1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,116 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible KCTD1-associated genes across cancer lineages are PIK3AP1, AQP4-AS1, and CIAPIN1P. Each is linked with KCTD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both KCTD1-to-partner and partner-to-KCTD1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KCTD1 versus PIK3AP1 in HNSC, with a Pearson correlation of -0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCTD1→partner) and Y-score (partner→KCTD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PIK3AP1 →	-0.822	-0.430	<.001	<.001	3	4
CCRCC	AQP4-AS1 →	+0.824	+0.551	<.001	<.001	3	4
LSCC	CIAPIN1P →	+0.834	+0.567	<.001	.004	3	4
HNSC	HSH2D →	-1.170	-0.467	<.001	.001	3	4
LSCC	RBM23 →	+0.366	+0.462	<.001	.004	3	3
LSCC	RPS6KA5 →	+0.587	+0.545	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,116 associations by consensus.

KCTD1 vs PIK3AP1 — HNSC

Explore this scatter interactively →