KCNV2

Across TCGA patient cohorts, KCNV2 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNV2-associated genes across cancer lineages are A-Raf_pS299, C-Raf, and Di-Ras3. Each is linked with KCNV2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNV2-to-partner and partner-to-KCNV2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by KCNV2-low versus KCNV2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNV2→partner) and Y-score (partner→KCNV2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.173	-2.000	<.001	.010	3	2
UCEC	C-Raf →	+0.231	+3.459	<.001	.005	3	2
UCEC	Di-Ras3 →	-0.201	-1.986	<.001	.029	3	2
UCEC	ACC1 →	+0.337	+1.750	.018	.049	3	2
UCEC	Src_pY416 →	-0.248	-3.143	.008	.018	3	2
UCEC	BRCA2 →	-0.108	-3.159	.030	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

A-Raf_pS299 by KCNV2 expression — UCEC

Explore this box plot interactively →