KCNT2

Across TCGA cell cohorts, KCNT2 mutation is significantly associated with the RNA expression of many other genes, with 118 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible KCNT2-associated genes across cancer lineages are OR3A1, MYH13, and ATP6V0B. Each is linked with KCNT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNT2-to-partner and partner-to-KCNT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR3A1 grouped by KCNT2-low versus KCNT2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNT2→partner) and Y-score (partner→KCNT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR3A1 →	+0.440	+2.616	<.001	.005	3	2
LUNG_SCLC	MYH13 →	+0.019	+2.616	<.001	.005	3	2
SKIN	ATP6V0B →	-0.449	-3.082	.002	.006	3	2
SKIN	S100A13 →	-0.762	-1.956	.001	.002	3	2
BLOOD_Myeloma	KRTAP19-3 →	+0.236	+4.807	<.001	.006	3	1
OESOPHAGUS	DAOA →	+0.062	+3.392	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 118 associations by consensus.

OR3A1 by KCNT2 expression — LUNG_SCLC

Explore this box plot interactively →