KCNQ5-AS1

Across TCGA pan-cancer cohorts, KCNQ5-AS1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated KCNQ5-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KCNQ5-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KCNQ5-AS1 expression acts as an unfavorable survival marker, although some lineages such as LAML and ESCA show a favorable association.

HNSC, THCA, and UCEC are the cancer types where KCNQ5-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.455	0.720	.001	54	view →
THCA	OS	Quartile	III,IV	0.579	0.968	.001	31	view →
UCEC	DFS	Tertile	All	0.321	0.672	.029	30	view →
LAML	DFS	Quartile	All	0.778	0.454	.001	28	view →
MESO	OS	Tertile	IV	0.077	0.592	.019	27	view →
KIRC	OS	Tertile	All	0.510	0.656	.004	24	view →
PAAD	DFS	Tertile	II,III,IV	0.306	0.463	.021	18	view →
LUSC	DFS	Tertile	III,IV	0.184	0.736	.016	18	view →
PCPG	OS	Quartile	All	0.820	1.000	.006	18	view →
BLCA	DFS	Tertile	IV	0.253	0.483	.011	15	view →
ESCA	OS	Tertile	IV	0.743	0.319	.017	12	view →
STAD	DFS	Tertile	IV	0.144	0.444	.012	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

KCNQ5-AS1–HNSC (OS)

Open the HNSC breakdown →