KCNQ4

Across TCGA pan-cancer cohorts, KCNQ4 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KCNQ4 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher KCNQ4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KCNQ4 expression acts as an unfavorable survival marker.

ESCA, LIHC, and UCEC are the cancer types where KCNQ4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.074	0.703	<.001	45	view →
LIHC	DFS	Median	II,III,IV	0.044	0.427	<.001	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUAD	OS	Median	All	0.323	0.834	.004	6	view →
COAD	OS	Median	All	0.523	0.879	<.001	5	view →
SKCM	OS	Median	III,IV	0.179	0.721	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KCNQ4–ESCA (OS)

Open the ESCA breakdown →