KCNQ1DN

Across TCGA pan-cancer cohorts, KCNQ1DN RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of KCNQ1DN’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where KCNQ1DN RNA is repressed in tumor relative to normal tissue. In most cancer types KCNQ1DN is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, LUAD, and KIRP are the cancer types where KCNQ1DN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCNQ1DN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.078	.001	9	view →
LUAD	Female	All	−0.085	<.001	6	view →
KIRP	All	All	−0.059	.001	6	view →
BRCA	All	All	−0.044	<.001	4	view →
KIRC	All	All	−0.022	.020	4	view →
HNSC	All	All	+0.038	.018	3	view →
UCEC	All	All	+0.140	.041	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

KCNQ1DN–KICH

Open the KICH breakdown →