KCNQ1

Across TCGA patient cohorts, KCNQ1 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,030 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible KCNQ1-associated proteins across cancer lineages are KCNQ1_S27, SORBS2, and PSMD3. Each is linked with KCNQ1 in more than 6 cancer types. Because this analysis shows association rather than direction, both KCNQ1-to-partner and partner-to-KCNQ1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KCNQ1 versus KCNQ1_S27 in LSCC, with a Pearson correlation of 0.60.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNQ1→partner) and Y-score (partner→KCNQ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KCNQ1_S27 →	+1.191	+0.811	<.001	<.001	3	7
OV	SORBS2 →	+0.647	+0.877	.003	.004	3	6
LSCC	PSMD3 →	-0.149	-0.606	<.001	.001	3	6
OV	TPX2_S486 →	-1.200	-0.844	.001	.002	3	5
LUAD	NCAPD2 →	-0.660	-1.153	<.001	<.001	3	5
LUAD	WDHD1 →	-0.631	-0.812	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,030 associations by consensus.

KCNQ1 vs KCNQ1_S27 — LSCC

Explore this scatter interactively →