KCNQ1

Across TCGA patient cohorts, KCNQ1 protein abundance is significantly associated with the RNA expression of many other genes, with 2,436 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible KCNQ1-associated genes across cancer lineages are MECOM-AS1, PMM2, and WDR4. Each is linked with KCNQ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNQ1-to-partner and partner-to-KCNQ1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KCNQ1 versus MECOM-AS1 in LUAD, with a Pearson correlation of 0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNQ1→partner) and Y-score (partner→KCNQ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MECOM-AS1 →	+0.938	+0.632	<.001	<.001	3	2
CCRCC	PMM2 →	-0.680	-0.448	<.001	.003	3	2
LUAD	WDR4 →	-0.415	-0.526	.001	.003	3	2
GBM	PGP →	-0.568	-0.528	.008	.001	3	2
LSCC	SETP4 →	-0.104	-0.734	.005	.002	3	2
PDAC	NANOGP7 →	+0.961	+0.582	.008	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,436 associations by consensus.

KCNQ1 vs MECOM-AS1 — LUAD

Explore this scatter interactively →